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Antony Carr
Director (Genome Damage and Stability)
E:
T: +44 (0)1273 678122 or +44 (0)1273 873118

Selected publications

Article

Pai, Chen-Chun, Kishkevich, Anastasiya, Deegan, Rachel S, Keszthelyi, Andrea, Folkes, Lisa, Kearsey, Stephen E, De León, Nagore, Soriano, Ignacio, de Bruin, Robertus Antonius Maria, Carr, Antony M and Humphrey, Timothy C (2017) Set2 methyltransferase facilitates DNA replication and promotes genotoxic stress responses through MBF-dependent transcription. Cell Reports, 20 (11). pp. 2693-2705. ISSN 2211-1247

Daigaku, Yasukazu, Etheridge, Thomas J, Nakazawa, Yuka, Nakayama, Mayumi, Watson, Adam T, Miyabe, Izumi, Ogi, Tomoo, Osborne, Mark A and Carr, Antony M (2017) PCNA ubiquitylation ensures timely completion of unperturbed DNA replication in fission yeast. PLoS Genetics, 13 (5). e1006789. ISSN 1553-7390

Fleck, Oliver, Fahnøe, Ulrik, Vyff Løvschal, Katrine, Uwamahoro Gasasira, Marie-Fabrice, Marinova, Irina N, Kragelund, Birthe B, Carr, Antony M, Hartsuiker, Edgar, Holmberg, Christian and Nielsen, Olaf (2017) Deoxynucleoside salvage in fission yeast allows rescue of ribonucleotide reductase deficiency but not Spd1-Mediated inhibition of replication. Genes, 8 (5). a128. ISSN 2073-4425

Kukalev, Alexander, Ng, Yiu-Ming, Ju, Limei, Saidi, Amal, Lane, Sophie, Mondragon, Angeles, Dormann, Dirk, Walker, Sophie E, Grey, William, Ho, Philip Wing-Lok, Stephens, David N, Carr, Antony M, Lamsa, Karri, Tse, Eric and Yu, Veronica (2016) Deficiency of Cks1 leads to learning and long-term memory defects and p27 dependentformation of neuronal cofilin aggregates. Cerebral Cortex, 27 (1). pp. 11-23. ISSN 1047-3211

Smith, Thomas C A, Carr, Antony M and Eyre-Walker, Adam C (2016) Are sites with multiple single nucleotide variants in cancer genomes a consequence of drivers, hypermutable sites or sequencing errors? PeerJ, 4. e2391. ISSN 2167-8359

Zeng, Ming, Laifeng, Ren, Mizuno, Ken'ichi, Nestoras, Konstantinos, Wang, Haibin, Tang, Zizhi, Guo, Liandi, Kong, Daochun, Hu, Qiwen, He, Qun, Du, Lilin, Carr, Antony M and Liu, Cong (2016) CRL4Wdr70 regulates H2B monoubiquitination and facilitates Exo1-dependent resection. Nature Communications, 7. p. 11364. ISSN 2041-1723

Mohebi, Saed, Mizuno, Ken'Ichi, Watson, Adam, Carr, Antony M and Murray, Johanne M (2015) Checkpoints are blind to replication restart and recombination intermediates that result in gross chromosomal rearrangements. Nature Communications, 6. p. 6357. ISSN 2041-1723

Daigaku, Yasukazu, Keszthelyi, Andrea, Müller, Carolin A, Miyabe, Izumi, Brooks, Tony, Retkute, Renata, Hubank, Mike, Nieduszynski, Conrad A and Carr, Antony M (2015) A global profile of replicative polymerase usage. Nature Structural and Molecular Biology, 22 (3). pp. 192-198. ISSN 1545-9993

Jeggo, Penny A, Pearl, Laurence H and Carr, Antony M (2015) DNA repair, genome stability and cancer: a historical perspective. Nature Reviews Cancer, 16 (1). pp. 35-42. ISSN 1474-175X

Herbert, Alex D, Carr, Antony M and Hoffmann, Eva (2014) FindFoci: a focus detection algorithm with automated parameter training that closely matches human assignments, reduces human inconsistencies and increases speed of analysis. PLoS ONE, 9 (12). e114749. ISSN 1932-6203

Etheridge, Thomas J, Boulineau, Rémi L, Herbert, Alex, Watson, Adam T, Daigaku, Yasukazu, Tucker, Jem, George, Sophie, Jönsson, Peter, Palayret, Matthieu, Lando, David, Laue, Ernest, Osborne, Mark A, Klenerman, David, Lee, Steven F and Carr, Antony M (2014) Quantification of DNA-associated proteins inside eukaryotic cells using single-molecule localization microscopy. Nucleic Acids Research, 42 (19). e146. ISSN 0305-1048

Wardlaw, Christopher P, Carr, Antony M and Oliver, Antony W (2014) TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways. DNA Repair, 22. pp. 165-174. ISSN 1568-7864

Gwon, Gwang Hyeon, Kim, Youngran, Liu, Yaqi, Watson, Adam, Jo, Aera, Etheridge, Thomas, Yuan, Fenghua, Zhang, Yanbin, Kim, YoungChang, Carr, Antony and Cho, Yunje (2014) Crystal structure of a Fanconi anemia-associated nuclease homolog bound to 5′ flap DNA: basis of interstrand cross-link repair by FAN1. Genes and Development, 28. pp. 2276-2290. ISSN 0890-9369

Etheridge, Thomas J, Boulineau, Rémi L, Herbert, Alex, Watson, Adam T, Daigaku, Yasukazu, Tucker, Jem, George, Sophie, Jönsson, Peter, Palayret, Matthieu, Lando, David, Laue, Ernest, Osborne, Mark A, Klenerman, David, Lee, Steven F and Carr, Antony M (2014) Quantification of DNA-associated proteins inside eukaryotic cells using single-molecule localization microscopy. Nucleic Acids Research, 42 (19). e146-e146. ISSN 0305-1048

Vejrup-Hansen, Rasmus, Fleck, Oliver, Landvad, Katrine, Fahnøe, Ulrik, Broendum, Sebastian S, Schreurs, Ann-Sofie, Kragelund, Birthe B, Carr, Antony M, Holmberg, Christian and Nielsen, Olaf (2014) Spd2 assists Spd1 in modulation of RNR architecture but does not regulate deoxynucleotide pools. Journal of Cell Science, 127. pp. 2460-2470. ISSN 0021-9533

Carr, Antony, Lambert, Sarah A E, Tsang, Ellen, Miyabe, Izumi, Iraqui, Ismail and Zheng, Jiping (2014) The extent of error-prone replication-restart by homologous recombination is controlled by Exo1 and checkpoint proteins. Journal of Cell Science, 127 (13). pp. 2983-2994. ISSN 0021-9533

Hart, LesleyRuth, Rauch, Anita, Carr, Antony, Vermeesch, Joris R and O'Driscoll, Mark (2014) LETM1 haploinsufficiency causes mitochondrial defects in cells from humans with Wolf-Hirschhorn syndrome: implications for dissecting the underlying pathomechanisms in this condition. Disease Models and Mechanisms, 7. pp. 535-545. ISSN 1754-8403

Watson, Adam T, Daigaku, Yasukazu, Mohebi, Saed, Etheridge, Thomas, Chahwan, Charley, Murray, Johanne M and Carr, Antony M (2013) Optimisation of the Schizosaccharomyces pombe urg1 expression system. PLoS ONE, 8 (12). e83800. ISSN 1932-6203

Fontebasso, Y, Etheridge, T J, Oliver, A W, Murray, J M and Carr, A M (2013) The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast. DNA Repair, 12 (12). pp. 1011-1023. ISSN 15687864

Carr, Antony, Wang, Zhao-Qi, WooKee, Min, Krueger, Anja, Bruhn, Christopher, Li, Tang-Liang, Liu, Cong and Zhou, Zhong-Wei (2013) An essential function for the ATR-Activation-Domain (AAD) of TopBP1 in mouse development and cellular senescence. PLoS Genetics, 9 (8). e1003702. ISSN 1553-7390

Lambert, Sarah and Carr, Antony M (2013) Replication stress and genome rearrangements: lessons from yeast models. Current Opinion in Genetics and Development, 23 (2). pp. 132-139. ISSN 0959-437X

Lambert, Sarah and Carr, Antony M (2013) Impediments to replication fork movement: stabilisation, reactivation and genome instability. Chromosoma, 122 (1-2). pp. 33-45. ISSN 0009-5915

Mizuno, Ken'ichi, Miyabe, Izumi, Schalbetter, Stephanie, Carr, Antony and Murray, Johanne (2013) Recombination-restarted replication makes inverted chromosome fusions at inverted repeats. Nature, 493. pp. 246-249. ISSN 0028-0836

Mizuno, Ken'ichi, Miyabe, Izumi, Schalbetter, Stephanie A, Carr, Antony M and Murray, Johanne M (2013) Recombination-restarted replication makes inverted chromosome fusions at inverted repeats. Nature, 493 (7431). pp. 246-249. ISSN 0028-0836

Dziadkowiec, D, Kramarz, K, Kanik, K, Wisniewski, P and Carr, A M (2013) Involvement of Schizosaccharomyces pombe rrp1+ and rrp2+ in the Srs2- and Swi5/Sfr1-dependent pathway in response to DNA damage and replication inhibition. Nucleic Acids Research, 41 (17). pp. 8196-8209. ISSN 0305-1048

Qu, Meng, Rappas, Mathieu, Wardlaw, Christopher P, Garcia, Valerie, Ren, Jing-Yi, Day, Matthew, Carr, Antony M, Oliver, Antony, Du, Li-Lin and Pearl, Laurence (2013) Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4TopBP1. Molecular Cell, 51 (6). pp. 723-736. ISSN 1097-2765

Tang, Zhaohua, Luca, Maria, Taggart-Murphy, Laura, Portillo, Jessica, Chang, Cathey, Guven, Ayse, Lin, Ren-Jang, Murray, Johanne and Carr, Antony (2012) Interacting factors and cellular localization of SR protein-specific kinase Dsk1. Experimental Cell Research, 318 (16). pp. 2071-2084. ISSN 0014-4827

Lando, David, Endesfelder, Ulrike, Berger, Harald, Subramanian, Lakxmi, Dunne, Paul D, McColl, James, Klenerman, David, Carr, Antony M, Sauer, Markus, Allshire, Robin C, Heilemann, Mike and Laue, Ernest D (2012) Quantitative single-molecule microscopy reveals that CENP-A(Cnp1) deposition occurs during G2 in fission yeast. Open Biology, 2 (7). p. 120078. ISSN 2046-2441

Lin, Su-Jiun, Wardlaw, Christopher Paul, Morishita, Takashi, Miyabe, Izumi, Chahwan, Charly, Caspari, Thomas, Schmidt, Ulrike, Carr, Antony and Garcia, Valerie (2012) The Rad4TopBP1 ATR-Activation domain functions in G1/S phase in a chromatin-dependent manner. PLoS Genetics, 8 (6). ISSN 1553-7390

Hu, Jiazhi, Sun, Lei, Shen, Fenfen, Chen, Yufei, Hua, Yu, Liu, Yang, Zhang, Mian, Hu, Yiren, Wang, Qingsong, Xu, Wei, Sun, Fei, Ji, Jianguo, Murray, Johanne M, Carr, Antony M and Kong, Daochun (2012) The intra-S phase checkpoint targets Dna2 to prevent stalled replication forks from reversing. Cell, 149 (6). pp. 1221-1232. ISSN 1097-4172

Miyabe, Izumi, Kunkel, Thomas A and Carr, Antony M (2011) The major roles of DNA polymerases epsilon and delta at the eukaryotic replication fork are evolutionarily conserved. PLoS Genetics, 7 (12). e1002407. ISSN 1553-7390

Mizuno, Ken'ichi, Lambert, Sarah, Baldacci, Giuseppe, Murray, Johanne M and Carr, Antony M (2009) Nearby inverted repeats fuse to generate acentric and dicentric palindromic chromosomes by a replication template exchange mechanism. Genes and Development, 23 (24). pp. 2876-2886. ISSN 0890-9369

Lloyd, Janette, Chapman, J. Ross, Clapperton, Julie A., Haire, Lesley F., Hartsuiker, Edgar, Li, Jiejin, Carr, Antony M., Jackson, Stephen P. and Smerdon, Stephen J. (2009) A supramodular FHA/BRCT-Repeat architecture mediates Nbs1 adaptor function in response to DNA damage. Cell, 139 (1). pp. 100-111. ISSN 0092-8674

Miyabe, Izumi, Morishita, Takashi, Shinagawa, Hideo and Carr, Antony M (2009) Schizosaccharomyces pombe Cds1 regulates homologous recombination at stalled replication forks through the phosphorylation of recombination protein Rad60. Journal of Cell Science, 122. pp. 3638-3643. ISSN 0021-9533

Dziadkowiec, Dorota, Petters, Edyta, Dyjankiewicz, Agnieszka, Karpinski, Pawel, Garcia, Valerie, Watson, Adam T. and Carr, Antony M. (2009) The role of novel genes rrp1(+) and rrp2(+) in the repair of DNA damage in Schizosaccharomycespombe. DNA Repair, 8 (5). pp. 627-636. ISSN 1568-7864

Hartsuiker, Edgar, Mizuno, Kenichi, Molnar, Monika, Kohli, Juerg, Ohta, Kunihiro and Carr, Antony M (2009) Ctp1(CtIP) and Rad32(Mre11) nuclease activity are required for Rec12(Spo11) removal, but Rec12(Spo11) removal Is dispensable for other MRN-Dependent meiotic functions. Molecular and Cellular Biology, 29 (7). pp. 1671-1681. ISSN 0270-7306

Hishida, T, Kubota, Y, Carr, Antony M and Iwasaki, H (2009) RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light. Nature, 457 (7229). pp. 612-615. ISSN 0028-0836

Frampton, Jonathan, Irmisch, Anja, Green, Catherine M, Neiss, Andrea, Trickey, Michelle, Ulrich, Helle D, Furuya, Kanji, Watts, Felicity, Carr, Antony M and Lehmann, Alan R (2006) Postreplication Repair and PCNA Modification in Schizosaccharomyces pombe. Molecular Biology of the Cell, 17 (7). pp. 2976-2985. ISSN 1059-1524

Holmberg, Christian, Fleck, Oliver, Hansen, Heidi A, Liu, Cong, Slaaby, Rita, Carr, Antony M and Nielsen, Olaf (2005) Ddb1 controls genome stability and meiosis in fission yeast. Genes and Development, 19 (7). pp. 853-862. ISSN 0890-9369

Caspari, Thomas, Murray, Johanne M and Carr, Antony M (2002) Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III. Genes and Development, 16 (10). pp. 1195-208. ISSN 0890-9369

Marchetti, Maria A, Kumar, Sanjay, Hartsuiker, Edgar, Maftahi, Mohamed, Carr, Antony M, Freyer, Greg A, Burhans, William C and Huberman, Joel A (2002) A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway. Proceedings of the National Academy of Sciences, 99 (11). pp. 7472-7477. ISSN 1091-6490

Mundt, Kirsten E, Porte, Joanne, Murray, Johanne M, Brikos, Constantinos, Christensen, Per U, Caspari, Thomas, Hagan, Iain M, Millar, Jonathan B A, Simanis, Viesturs, Hofmann, Kay and Carr, Anthony M (1999) The COP9/signalosome complex is conserved in fission yeast and has a role in S phase. Current Biology, 9 (23). pp. 1427-1430.

Lindsay, Howard D, Griffiths, Dominic J, Edwards, Rhian J, Christensen, Per U, Murray, Johanne M, Osman, Fekret, Walworth, Nancy and Carr, Antony M (1998) S-phase-specific activation of Cds1 kinase defines a subpathway of the checpoint response in Schizosaccharomyces pombe. Genes and Development, 12 (3). pp. 382-395. ISSN 0890-9369