Photo of Simon Morley

Simon Morley
Professor of Signal Transduction (Biochemistry)
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T: +44 (0)1273 872794


Selected publications

Article

Lineham, Ella, Spencer, John and Morley, Simon (2017) Dual abrogation of Mnk and mTOR; a novel therapeutic approach for the treatment of aggressive cancers. Future Medicinal Chemistry, 9 (13). ISSN 1756-8919

Copsey, Alice C, Cooper, Simon, Parker, Robert, Lineham, Ella, Lapworth, Cuzack, JALLAD, Deema Basil Sadiq, Sweet, Steve and Morley, Simon J (2017) The helicase, DDX3X, interacts with poly(A) binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading. Biochemical Journal, 474 (18). pp. 3109-3120. ISSN 0264-6021

Jongjitwimol, Jirapas, Baldock, Robert A, Morley, Simon J and Watts, Felicity Z (2016) Sumoylation of eIF4A2 affects stress granule formation. Journal of Cell Science, 129 (12). pp. 2407-2415. ISSN 0021-9533

Pollard, Hilary J, Willett, Mark and Morley, Simon J (2014) mTOR kinase-dependent, but raptor-independent regulation of downstream signaling is important for cell cycle exit and myogenic differentiation. Cell Cycle, 13 (16). pp. 2517-2525. ISSN 1538-4101

Jongjitwimol, Jirapas, Feng, Min, Zhou, Lihong, Wilkinson, Oliver, Small, Lauren, Baldock, Robert, Taylor, Deborah L, Smith, Duncan, Bowler, Lucas, Morley, Simon J and Watts, Felicity (2014) The S. pombe translation initiation factor eIF4G is sumoylated and associates with the SUMO protease Ulp2. PLoS ONE, 9 (5). e94182. ISSN 1932-6203

Smalley, Sarah, Chalmers, Anthony J and Morley, Simon J (2014) mTOR inhibition and levels of the DNA repair protein MGMT in T98G glioblastoma cells. Molecular Cancer, 13 (1). p. 144. ISSN 1476-4598

Coldwell, Mark J, Cowan, Joanne L, Vlasak, Markete, Mead, Abbie, Willett, Mark, Perry, Lisa S and Morley, Simon J (2013) Phosphorylation of eIF4GII and 4E-BP1 in response to nocodazole treatment: a reappraisal of translation initiation during mitosis. Cell Cycle, 12 (23). pp. 3615-3628. ISSN 1538-4101

Clemens, Michael J, Elia, Androulla and Morley, Simon J (2013) Requirement for the eIF4E binding proteins for the synergistic down-regulation of protein synthesis by hypertonic conditions and mTOR inhibition. PLoS ONE, 8 (8). e71138. ISSN 1932-6203

Willett, Mark, Brocard, Michele, Pollard, Hilary J and Morley, Simon J (2013) mRNA encoding WAVE-Arp2/3-associated proteins is co-localized with foci of active protein synthesis at the leading edge of MRC5 fibroblasts during cell migration. The Biochemical Journal, 452 (1). pp. 45-55. ISSN 1470-8728

Coldwell, Mark J, Sack, Ulrike, Cowan, Joanne L, Barrett, Rachel M, Vlasak, Markete, Sivakumaran, Keiley and Morley, Simon J (2012) Multiple isoforms of the translation initiation factor eIF4GII are generated via use of alternative promoters, splice sites and a non-canonical initiation codon. Biochemical Journal, 448 (1). pp. 1-11. ISSN 0264-6021

González-Estévez, Cristina, Felix, Daniel A, Smith, Matthew D, Paps, Jordi, Morley, Simon J, James, Victoria, Sharp, Tyson V and Aboobaker, A Aziz (2012) SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians. PLoS Genetics, 8 (3). e1002619. ISSN 1553-7390

Vosler, Peter S, Gao, Yanqin, Brennan, Christopher S, Yanagiya, Akiko, Gan, Yu, Cao, Guodong, Zhang, Feng, Morley, Simon J, Sonenberg, Nahum, Bennett, Michael V L and Chen, Jun (2011) Ischemia-induced calpain activation causes eukaryotic (translation) initiation factor 4G1 (eIF4GI) degradation, protein synthesis inhibition, and neuronal death. Proceedings of the National Academy of Sciences, 108 (44). pp. 18102-18107. ISSN 1091-6490

Morley, Simon, Brocard, Michele, Davide, Alexandre and Willett, Mark (2011) Translation initiation factors and active sites of protein synthesis co-localise at the leading edge of migrating MRC5 fibroblasts. Biochemical Journal, 438 (1). pp. 217-227. ISSN 0264-6021

Willett, Mark, Brocard, Michele, Davide, Alexandre and Morley, Simon J (2011) Translation initiation factors and active sites of protein synthesis co-localize at the leading edge of migrating fibroblasts. The Biochemical Journal, 438 (1). pp. 217-227. ISSN 1470-8728

Bhatia, Payal, Menigatti, Mirco, Brocard, Michele, Morley, Simon J and Ferrari, Stefano (2010) Mitotic DNA damage targets the Aurora A/TPX2 complex. Cell Cycle, 9 (22). pp. 4592-4599. ISSN 1538-4101

James, Victoria, Zhang, Yining, Foxler, Daniel E, de Moor, Cornelia H, Kong, Yi Wen, Webb, Thomas M, Self, Tim J, Feng, Yungfeng, Lagos, Dimitrios, Chu, Chia-Ying, Rana, Tariq M, Morley, Simon J, Longmore, Gregory D, Bushell, Martin and Sharp, Tyson V (2010) LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. Proceedings of the National Academy of Sciences, 107 (28). pp. 12499-12504. ISSN 0027-8424

Willett, Mark, Pollard, Hilary J, Vlasak, Marketa and Morley, Simon J (2010) Localization of ribosomes and translation initiation factors to talin/beta3-integrin-enriched adhesion complexes in spreading and migrating mammalian cells. Biology of the Cell, 102 (5). pp. 265-276. ISSN 0248-4900

Willett, Mark, Cowan, Joanne L, Vlasak, Markete, Coldwell, Mark J and Morley, Simon J (2009) Inhibition of mammalian target of rapamycin (mTOR) signalling in C2C12 myoblasts prevents myogenic differentiation without affecting the hyperphosphorylation of 4E-BP1. Cellular Signalling, 21 (10). pp. 1504-1512. ISSN 0898-6568

Morley, Simon J and Willett, Mark (2009) Kinky Binding and SECsy Insertions. Molecular Cell, 35 (4). pp. 396-398. ISSN 1097-2765

Spriggs, Keith A, Cobbold, Laura C, Jopling, Catherine L, Cooper, Rebecca E, Wilson, Lindsay A, Stoneley, Mark, Coldwell, Mark J, Poncet, Didier, Shen, Ya-Ching, Morley, Simon, Bushell, Martin and Willis, Anne E (2009) Canonical initiation factor requirements of the Myc family of internal ribosome entry segments. Molecular and Cellular Biology, 29 (6). pp. 1565-1574. ISSN 0270-7306

Morley, Simon J and Willett, Mark (2008) Signaling Pathways Open the GAITway to Translational Control. Developmental Cell, 15 (5). pp. 639-640. ISSN 1534-5807

Morley, Simon J and Coldwell, Mark J (2008) A Cunning Stunt: An Alternative Mechanism of Eukaryotic Translation Initiation. Science Signaling, 1 (25). ISSN 1945-0877

Morley, S and Cook, S (2007) Nutrient-responsive mTOR signalling grows on sterile ground. Biochemical Journal, 403 (1). e1-e3. ISSN 0264-6021

Coldwell, Mark J and Morley, Simon J (2006) Specific isoforms of translation initiation factor 4GI show differences in translational activity. Molecular and Cellular Biology, 26 (22). pp. 8448-8460. ISSN 0270-7306

Ling, Jun, Morley, Simon J and Traugh, Jolinda A (2005) Inhibition of cap-dependent translation via phosphorylation of eIF4G by protein kinase Pak2. EMBO Journal, 24 (23). pp. 4094-4105. ISSN 0261-4189

Naegele, Susanne and Morley, Simon J (2004) Molecular Cross-talk between MEK1/2 and mTOR Signaling during Recovery of 293 Cells from Hypertonic Stress. Journal of Biological Chemistry, 279 (44). pp. 46023-46034. ISSN 0021-9258

Morley, Simon J and Naegele, Susanne (2002) Phosphorylation of eukaryotic initiation factor (eIF) 4E is not required for de novo protein synthesis following recovery from hypertonic stress in human kidney cells. Journal of Biological Chemistry, 277 (36). pp. 32855-32859. ISSN 0021-9258

Ali, Iraj K, McKendrick, Linda, Morley, Simon J and Jackson, Richard J (2001) Truncated initiation factor eIF4G lacking an eIF4E binding site can support capped mRNA translation. EMBO Journal, 20 (15). pp. 4233-4242. ISSN 0261-4189

McKendrick, Linda, Thompson, Elizabeth, Ferreira, Joao, Morley, Simon J and Lewis, Joe D (2001) Interaction of eukaryotic translation initiation factor 4G with the nuclear cap-binding complex provides a link between nuclear and cytoplasmic functions of the m7 guanosine cap. Molecular and Cellular Biology, 21 (11). pp. 3632-3641. ISSN 0270-7306