Selected publications

Article

Al-Hilaly, Youssra K, Pollack, Saskia J, Vadukul, Devkee, Citossi, Francesca, Rickard, Janet E, Simpson, Michael, Storey, John M D, Harrington, Charles R, Wischik, Claude M and Serpell, Louise C (2017) Alzheimer's disease-like paired helical filament assembly from truncated tau protein is independent of disulphide cross-linking. Journal of Molecular Biology. ISSN 0022-2836

Kubánková, Markéta, López-Duarte, Ismael, Bull, James A, Vadukul, Devkee M, Serpell, Louise C, de Saint Victor, Marie, Stride, Eleanor and Kuimova, Marina K (2017) Probing supramolecular protein assembly using covalently attached fluorescent molecular rotors. Biomaterials, 139. pp. 195-201. ISSN 0142-9612

Al-Garawi, Z S, McIntosh, B A, Neill-Hall, D, Hatimy, A A, Sweet, S M, Bagley, M C and Serpell, L C (2017) The amyloid architecture provides a scaffold for enzyme-like catalysts. Nanoscale (30). pp. 10773-10783. ISSN 2040-3364

Ardoña, Herdeline Ann M, Draper, Emily R, Citossi, Francesca, Wallace, Matthew, Serpell, Louise C, Adams, Dave J and Tovar, John D (2017) Kinetically controlled coassembly of multichromophoric peptide hydrogelators and the impacts on energy transport. Journal of the American Chemical Society, 139 (25). pp. 8685-8692. ISSN 0002-7863

Linke, Reinhold P, Serpell, Louise C, Lottspeich, Friedrich and Toyoda, Mitsuyasu (2017) Cathepsin K as a novel amyloid fibril protein in humans. Amyloid, 24 (1). pp. 68-69. ISSN 1350-6129

Ford, Lenzie, Crossley, Michael, Vadukul, Devkee M, Kemenes, György and Serpell, Louise C (2017) Structure dependent effects of Amyloid-β on long-term memory in Lymnaea stagnalis. FEBS Letters, 591 (9). pp. 1236-1246. ISSN 0014-5793

Vadukul, Devkee M, Gbajumo, Oyinkansola, Marshall, Karen E and Serpell, Louise C (2017) Amyloidogenicity and toxicity of the reverse and scrambled variants of amyloid-β 1-42. FEBS Letters, 591 (5). pp. 822-830. ISSN 0014-5793

Colquhoun, Catherine, Draper, Emily R, Schweins, Ralf, Marcello, Marco, Vadukul, Devkee, Serpell, Louise C and Adams, Dave J (2017) Controlling the network type in self-assembled dipeptide hydrogels. Soft Matter, 13 (9). pp. 1914-1919. ISSN 1744-683X

Al-Hilaly, Youssra K, Biasetti, Luca, Brakeman, Ben J, Pollack, Saskia J, Zibaee, Shahin, Abdul-Sada, Alaa, Thorpe, Julian R, Xue, Wei-Feng and Serpell, Louise C (2016) The involvement of dityrosine crosslinking in α-synuclein assembly and deposition in Lewy Bodies in Parkinson’s disease. Scientific Reports, 6. p. 39171. ISSN 2045-2322

Al-Garawi, Zahraa S, Kostakis, Georgios E and Serpell, Louise C (2016) Chemically and thermally stable silica nanowires with a β-sheet peptide core for bionanotechnology. Journal of Nanobiotechnology, 14. p. 79. ISSN 1477-3155

Gallardo, Rodrigo, Ramakers, Meine, De Smet, Frederik, Claes, Filip, Khodaparast, Ladan, Khodaparast, Laleh, Couceiro, José R, Langenberg, Tobias, Siemons, Maxime, Nyström, Sofie, Young, Laurence J, Laine, Romain F, Young, Lydia, Radaelli, Enrico, Benilova, Iryna, Kumar, Manoj, Staes, An, Desager, Matyas, Beerens, Manu, Vandervoort, Petra, Luttun, Aernout, Gevaert, Kris, Bormans, Guy, Dewerchin, Mieke, Van Eldere, Johan, Carmeliet, Peter, Vande Velde, Greetje, Verfaillie, Catherine, Kaminski, Clemens F, De Strooper, Bart, Hammarström, Per, Nilsson, K Peter R, Serpell, Louise, Schymkowitz, Joost and Rousseau, Frederic (2016) De novo design of a biologically active amyloid. Science, 354 (6313). aah4949. ISSN 0036-8075

Sant’Anna, Ricardo, Fernández, Maria Rosario, Batlle, Cristina, Navarro, Susanna, de Groot, Natalia S, Serpell, Louise and Ventura, Salvador (2016) Characterization of amyloid cores in prion domains. Scientific Reports, 6. a34274. ISSN 2045-2322

Marshall, Karen E, Vadukul, Devkee M, Dahal, Liza, Theisen, Alina, Fowler, Milena W, Al-Hilaly, Youssra, Ford, Lenzie, Kemenes, György, Day, Iain J, Staras, Kevin and Serpell, Louise (2016) A critical role for the self-assembly of Amyloid-β1-42 in neurodegeneration. Scientific Reports, 6. ISSN 2045-2322

Williams, Thomas L, Serpell, Louise C and Urbanc, Brigita (2016) Stabilization of native amyloid β-protein oligomers by Copper and Hydrogen peroxide Induced Cross-linking of Unmodified Proteins (CHICUP). BBA - Proteins and Proteomics, 1864 (3). pp. 249-259. ISSN 1570-9639

Joyce, Rebecca E, Williams, Thomas L, Serpell, Louise C and Day, Iain J (2016) Monitoring changes of paramagnetically-shifted 31P signals in phospholipid vesicles. Chemical Physics Letters. ISSN 0009-2614

Al-Garawi, Zahraa S, Thorpe, Julian R and Serpell, Louise C (2015) Silica nanowires templated by amyloid-like fibrils. Angewandte Chemie International Edition, 54 (45). pp. 13327-13331. ISSN 1433-7851

Al-Garawi, Zahraa S, Thorpe, Julian R and Serpell, Louise C (2015) Silica nanowires templated by amyloid-like fibrils. Angewandte Chemie, 127 (45). pp. 13525-13529. ISSN 0044-8249 (Accepted)

Williams, Thomas L, Urbanc, Brigita, Marshall, Karen E, Vadukul, Devkee M, Jenkins, A Toby A and Serpell, Louise C (2015) Europium as an inhibitor of Amyloid-β(1-42) induced membrane permeation. FEBS Letters, 589 (21). pp. 3228-3236. ISSN 0014-5793

Burgess, Natasha C, Sharp, Thomas H, Thomas, Franziska, Wood, Christopher W, Thomson, Andrew R, Zaccai, Nathan R, Brady, R Leo, Serpell, Louise C and Woolfson, Derek N (2015) Modular design of self-assembling peptide-based nanotubes. Journal of the American Chemical Society, 137 (33). pp. 10554-10562. ISSN 0002-7863

Ford, Lenzie, Crossley, Michael, Williams, Thomas, Thorpe, Julian R, Serpell, Louise C and Kemenes, György (2015) Effects of Aβ exposure on long-term associative memory and its neuronal mechanisms in a defined neuronal network. Scientific Reports, 5. p. 10614. ISSN 2045-2322

Ford, Lenzie, Crossley, Michael, Williams, Thomas, Thorpe, Julian R, Serpell, Louise C and Kemenes, György (2015) Effects of Aβ exposure on longterm associative memory and its neuronal mechanisms in a defined neuronal network. Scientific Reports, 5. p. 10614. ISSN 2045-2322

Kaltofen, Sabine, Li, Chenge, Huang, Po-Ssu, Serpell, Louise C, Barth, Andreas and André, Ingemar (2015) Computational de novo design of a self-assembling peptide with predefined structure. Journal of Molecular Biology, 427 (2). pp. 550-562. ISSN 0022-2836

Ratnayaka, J A, Serpell, L C and Lotery, A J (2015) Dementia of the eye: the role of amyloid beta in retinal degeneration. Eye, 29. pp. 1013-1026. ISSN 0950-222X

Morris, Kyle L, Chen, Lin, Rodger, Alison, Adams, Dave J and Serpell, Louise C (2015) Structural determinants in a library of low molecular weight gelators. Soft Matter, 11 (6). pp. 1174-1181. ISSN 1744-683X

Langkilde, A E, Morris, K L, Serpell, L C, Svergun, D I and Vestergaard, B (2015) The architecture of amyloid-like peptide fibrils revealed by X-ray scattering, diffraction and electron microscopy. Acta Crystallographica Section D: Biological Crystallography, 71 (4). pp. 882-895. ISSN 1399-0047

Colquhoun, Catherine, Draper, Emily R, Eden, Edward G B, Cattoz, Beatrice N, Morris, Kyle, Chen, Lin, McDonald, Tom O, Terry, Ann E, Griffiths, Peter C, Serpell, Louise C and Adams, Dave J (2014) The effect of self-sorting and co-assembly on the mechanical properties of low molecular weight hydrogels. Nanoscale, 22 (6). pp. 13719-13725. ISSN 2040-3364

Sanders, David W, Kaufman, Sarah K, DeVos, Sarah L, Sharma, Apurwa M, Mirbaha, Hilda, Li, Aimin, Barker, Scarlett J, Foley, Alex C, Thorpe, Julian R, Serpell, Louise C, Miller, Timothy M, Grinberg, Lea T, Seeley, William W and Diamond, Marc I (2014) Distinct tau prion strains propagate in cells and mice and define different tauopathies. Neuron, 82 (6). pp. 1271-1288. ISSN 0896-6273

Marshall, Karen E, Marchante, Ricardo, Xue, Wei-Feng and Serpell, Louise C (2014) The relationship between amyloid structure and cytotoxicity. Prion, 8 (2). pp. 5-4. ISSN 1933-6896

Al-Hilaly, Youssra K, Williams, Thomas L, Stewart-Parker, Maris, Ford, Lenzie, Skaria, Eldhose, Cole, Michael, Bucher, William, Morris, Kyle L, Sada, Alaa, Thorpe, Julian R and Serpell, Louise C (2013) A central role for dityrosine crosslinking of Amyloid-β in Alzheimer’s disease. Acta Neuropathologica Communications, 1 (83). pp. 1-17. ISSN 2051-5960

Morris, Kyle L, Zibaee, Shahin, Chen, Lin, Goedert, Michel, Sikorski, Pawel and Serpell, Louise C (2013) The structure of cross-β tapes and tubes formed by an octapeptide, αSβ1. Angewandte Chemie International Edition, 52 (8). pp. 2279-2283. ISSN 1433-7851

Morris, Kyle L, Chen, Lin, Raeburn, Jaclyn, Sellick, Owen R, Cotanda, Pepa, Paul, Alison, Griffiths, Peter C, King, Stephen M, O’Reilly, Rachel K, Serpell, Louise C and Adams, Dave J (2013) Chemically programmed self-sorting of gelator networks. Nature Communications, 4. p. 1480. ISSN 2041-1723

Morris, Kyle L, Rodger, Alison, Hicks, Matthew R, Debulpaep, Maya, Schymkowitz, Joost, Rousseau, Frederic and Serpell, Louise C (2012) Exploring the sequence-structure relationship for amyloid peptides. Biochemical Journal, 450. pp. 275-283. ISSN 0264-6021

Soura, Violetta, Stewart-Parker, Maris, Williams, Thomas L, Ratnayaka, Arjuna, Atherton, Joe, Gorringe, Kirsti, Tuffin, Jack, Darwent, Elisabeth, Rambaran, Roma, Klein, William, Lacor, Pascale, Staras, Kevin, Thorpe, Julian and Serpell, Louise (2012) Visualisation of co-localisation in Ab42-administered neuroblastoma cells reveals lysosome damage and autophagosome accumulation related to cell death. Biochemical Journal, 441 (2). pp. 579-590. ISSN 0264-6021

Soura, Violetta, Stewart‑Parker, Maris, Williams, Thomas L, Ratnayaka, Arjuna, Atherton, Joe, Gorringe, Kirsti, Tuffin, Jack, Darwent, Elisabeth, Rambaran, Roma, Klein, William, Lacor, Pascale, Staras, Kevin and Serpell, Louise C (2012) Visualization of co-localization in Aβ42-administered neuroblastoma cells reveals lysosome damage and autophagosome accumulation related to cell death. Biochemical Journal, 441 (2). pp. 579-590. ISSN 0264-6021

Williams, Thomas L, Johnson, Benjamin R G, Urbanc, Brigita, Jenkins, A Toby A, Connell, Simon D A and Serpell, Louise C (2011) Alzheimer's Aß42 oligomers but not fibrils simultaneously bind to and cause damage to ganglioside containing lipid membranes. Biochemical Journal, 439. pp. 67-77.

Marshall, Karen, Morris, Kyle L, Charlton, Deborah, O’Reilly, Nicola, Lewis, Laurence, Walden, Helen and Serpell, Louise C (2011) Hydrophobic, aromatic and electrostatic interactions play a central role in amyloid fibril formation. Biochemistry, 50 (12). pp. 2061-2071. ISSN 0006-2960

Serpell, Louise, Adams, Dave, Chen, Lin, Lotze, Gudrun, Morris, Kyle, Pont, Guillaume and Squires, Adam (2011) Salt-induced hydrogelation of functionalised-dipeptides at high pH. Chemical Communications, 47. 12071 - 12073. ISSN 1359-7345

Serpell, Louise, Crowther, Damian, Hider, Robert, Liu, Beinan, Lomas, David, Marciniak, Stefan, Meehan, Sarah, Moloney, Aileen, Morris, Kyle and Thomas, Sally (2010) Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation. Journal of Biological Chemistry, 286. pp. 4248-4256. ISSN 0021-9258

Serpell, Louise, Day, Iain and Williams, Thomas (2010) The effect of Alzheimer's Aß aggregation state on the permeation of biomimetic lipid vesicles. Langmuir, 26 (22). pp. 17260-17268. ISSN 0743-7463

Tamamis, Phanourios, Adler-Abramovich, Lihi, Reches, Meital, Marshall, Karen, Sikorski, Pawel, Serpell, Louise, Gazit, Ehud and Archontis, Georgios (2009) Self-Assembly of Phenylalanine Oligopeptides: Insights from Experiments and Simulations. Biophysical Journal, 96 (12). pp. 5020-5029. ISSN 0006-3495

Marshall, Karen E and Serpell, Louise C (2009) The structural integrity of β-sheet assembly. Biochemical Society Transactions, 37 (4). pp. 671-676. ISSN 0300-5127

Madine, Jillian, Copland, Alastair, Serpell, Louise C and Middleton, David A (2009) Cross-ß spine architecture of fibrils formed by the amyloidogenic segment NFGSVQFV of medin from solid-state NMR and X-ray fibre diffraction measurements. Biochemistry, 48 (14). pp. 3089-3099. ISSN 0006-2960

Banwell, Eleanor F, Abelardo, Edgardo S, Adams, Dave J, Birchall, Martin A, Corrigan, Adam, Donald, Athene M, Kirkland, Mark, Serpell, Louise C, Butler, Michael F and Woolfson, Derek N (2009) Rational design and application of alpha-helical peptide hydrogels. Nature Materials, 8 (7). pp. 596-600. ISSN 1476-1122

Madine, Jillian, Jack, Edward, Stockley, Peter G, Radford, Sheena E, Serpell, Louise C and Middleton, David A (2008) Structural insights into the polymorphism of amyloid-like fibrils formed by region 20-29 of amylin revealed by solid-state NMR and X-ray fibre diffraction. Journal of American Chemical Society, 130 (45). pp. 14990-15001. ISSN 0002-7863

Rambaran, Roma N and Serpell, Louise C (2008) Amyloid fibrils: abnormal protein assembly. Prion, 2 (3). pp. 112-117. ISSN 1933-690X

Fukuma, Takeshi, Mostaert, Anika S, Serpell, Louise C and Jarvis, Suzanne P (2008) Revealing molecular-level surface structure of amyloid fibrils in liquid by means of frequency modulation atomic force microscopy. Nanotechnology, 19 (38). pp. 384010-384016. ISSN 0957-4484

Zibaee, Shahin, Jakes, Ross, Fraser, Graham, Serpell, Louise C, Crowther, R Anthony and Goedert, Michel (2007) Sequence Determinants for Amyloid Fibrillogenesis of Human a-Synuclein. Journal of Molecular Biology, 374 (2). pp. 454-464. ISSN 0022-2836

Makin, O Sumner, Sikorski, Pawel and Serpell, Louise C (2007) CLEARER: a new tool for the analysis of X-ray fibre diffraction patterns and diffraction simulation from atomic structural models. Journal of Applied Crystallography, 40 (5). pp. 966-972. ISSN 0021-8898

Zibaee, Shahin, Makin, O Sumner, Goedert, Michel and Serpell, Louise C (2007) A simple algorithm locates beta-strands in the amyloid fibril core of alpha-synuclein, Abeta, and tau using the amino acid sequence alone. Protein Science, 16 (5). pp. 906-918. ISSN 1469-896X

Slotta, Ute, Hess, Simone, Spieß, Kristina, Stromer, Thusnelda, Serpell, Louise and Scheibel, Thomas (2007) Spider Silk and Amyloid Fibrils: A Structural Comparison. Macromolecular Bioscience, 7 (2). pp. 183-188. ISSN 1616-5187

Serpell, Louise C, Benson, Merrill, Liepnieks, Juris J and Fraser, Paul E (2007) Structural analyses of fibrinogen amyloid fibrils. Amyloid, 14 (3). pp. 199-203. ISSN 1350-6129

Stanley, Peter, Serpell, Louise C and Stein, Penelope E (2006) Polymerization of human angiotensinogen: insights into its structural mechanism and functional significance. Biochemical Journal, 400 (1). pp. 169-178. ISSN 0264-6021

Makin, O Sumner, Sikorski, Pawel and Serpell, Louise C (2006) Diffraction to study protein and peptide assemblies. Current Opinion in Chemical Biology, 10 (5). pp. 417-422. ISSN 1367-5931

Li, Wei, Serpell, Louise C, Carter, Wendy J, Rubinsztein, David C and Huntington, James A (2006) Expression and Characterization of Full-length Human Huntingtin, an Elongated HEAT Repeat Protein. Journal of Biological Chemistry, 281 (23). pp. 15916-15922. ISSN 0021-9258

Yoshida, Hirotaka, Craxton, Molly, Jakes, Ross, Zibaee, Shahin, Tavare, Richard, Fraser, Graham, Serpell, Louise, Davletov, Bazbek, Crowther, R. Anthony and Goedert, Michel (2006) Synuclein Proteins of the Pufferfish Fugu rubripes: Sequences and Functional Characterization. Biochemistry, 45 (8). pp. 2599-2607. ISSN 0006-2960

Makin, O Sumner and Serpell, Louise C (2005) Structures for amyloid fibrils (mini-review). FEBS Journal, 272 (23). pp. 5950-5961. ISSN 1742-464X

Stromer, Thusnelda and Serpell, Louise C (2005) Structure and morphology of the Alzheimer's amyloid fibril. Microscopy Research and Technique, 67 (3-4). pp. 210-217. ISSN 1059-910X

Makin, O Sumner, Atkins, Edward, Sikorski, Pawel, Johansson, Jan and Serpell, Louise C (2005) Molecular basis for amyloid fibril formation and stability. Proceedings of the National Academy of Sciences, 102 (2). pp. 315-320. ISSN 0027-8424

Makin, O Sumner and Serpell, Louise C (2004) X-Ray Diffraction Studies of Amyloid Structure. Methods in Molecular Biology, 299. pp. 67-80. ISSN 1064-3745

Choi, Woong, Zibaee, Shahin, Jakes, Ross, Serpell, Louise C, Davletov, Bazbek, Crowther, R Anthony and Goedert, Michel (2004) Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein . FEBS Letters, 576 (3). pp. 363-368. ISSN 0014-5793

Dafforn, Timothy R, Rajendra, Jacindra, Halsall, David J, Serpell, Louise C and Rodger, Alison (2004) Protein Fiber Linear Dichroism for Structure Determination and Kinetics in a Low-Volume, Low-Wavelength Couette Flow Cell. Biophysical Journal, 86 (1). pp. 404-410. ISSN 0006-3495

Makin, O Sumner and Serpell, Louise C (2004) Structural characterisation of islet amyloid polypeptide fibrils. Journal of Molecular Biology, 335 (5). pp. 1279-1288. ISSN 0022-2836

Makin, O Sumner and Serpell, Louise C (2004) The Structure of Amyloid. Fibre Diffraction Review, 12. pp. 29-35. ISSN 1463-8401

Serpell, L, Blake, C and Sunde, M (1997) The molecular basis of amyloidosis. Cellular and Molecular Life Sciences, 53 (11-12). pp. 871-887. ISSN 1420-682X

Book Section

Scheibel, Thomas and Serpell, Louise (2005) Physical Methods for Studies of Fiber Formation and Structure. In: Protein folding handbook. Wiley-VCH, pp. 197-253. ISBN 9783527307845

Patent

University of Sussex (2016) Alzheimer's disease. .