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Aidan Doherty
Professor of Biochemistry (Genome Damage and Stability)
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T: +44 (0)1273 877500 or +44 (0)1273 873120


Selected publications

Article

Plocinski, Przemyslaw, Brissett, Nigel C, Bianchi, Julie, Brzostek, Anna, Korycka-Machała, Małgorzata, Dziembowski, Andrzej, Dziadek, Jaroslaw and Doherty, Aidan J (2017) DNA Ligase C and Prim-PolC participate in base excision repair in mycobacteria. Nature Communications, 1251 (2017). ISSN 2041-1723

Guilliam, Thomas A, Brissett, Nigel C, Ehlinger, Aaron, Keen, Benjamin A, Kolesar, Peter, Taylor, Elaine, Bailey, Laura J, Lindsay, Howard, Chazin, Walter J and Doherty, Aidan J (2017) Molecular basis for PrimPol recruitment to replication forks by RPA. Nature Communications, 8. a15222. ISSN 2041-1723

Bailey, Laura and Doherty, Aidan (2017) Mitochondrial DNA replication: a PrimPol perspective. Biochemical Society Transactions, 45 (2). pp. 513-529. ISSN 0300-5127 (Accepted)

Castañeda-García, A, Prieto, A I, Rodríguez-Beltrán, J, Alonso, N, Cantillon, D, Costas, C, Pérez-Lago, L, Zegeye, E D, Herranz, M, Plociński, P, Tonjum, T, García de Viedma, D, Paget, M, Waddell, S J, Rojas, A M, Doherty, A J and Blázquez, J (2017) A non-canonical mismatch repair pathway in prokaryotes. Nature Communications, 8. a14246. ISSN 2041-1723

Kobayashi, Kaori, Guilliam, Thomas A, Tsuda, Masataka, Yamamoto, Junpei, Bailey, Laura J, Iwai, Shigenori, Takeada, Shunichi, Doherty, Aidan J and Hirota, Kouji (2016) Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain terminating nucleosides. Cell Cycle, 15 (15). pp. 1997-2008. ISSN 1538-4101

Kobayashi, Kaori, Guilliam, Thomas A, Tsuda, Masataka, Yamamoto, Junpei, Bailey, Laura J, Iwai, Shigenori, Takeda, Shunichi, Doherty, Aidan J and Hirota, Kouji (2016) Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides. Cell Cycle, 15 (15). pp. 1997-2008. ISSN 1538-4101

Guilliam, Thomas A, Bailey, Laura J, Brissett, Nigel C and Doherty, Aidan J (2016) PolDIP2 interacts with human PrimPol and enhances its DNA polymerase activities. Nucleic Acids Research, 44 (7). pp. 3317-3329. ISSN 0305-1048

Guilliam, Thomas A, Bailey, Laura J, Brissett, Nigel C and Doherty, Aidan J (2016) PolDIP2 interacts with human PrimPol and enhances its DNA polymerase activities. Nucleic Acids Research, 44 (7). pp. 3317-3329. ISSN 0305-1048

Schiavone, Davide, Jozwiakowski, Stanislaw K, Romanello, Marina, Guilbaud, Guillaume, Guilliam, Thomas A, Bailey, Laura J, Sale, Julian E and Doherty, Aidan J (2016) PrimPol is required for replicative tolerance of G quadruplexes in vertebrate cells. Molecular Cell, 61 (1). pp. 161-169. ISSN 1097-2765

Bailey, Laura J, Bianchi, Julie, Hegarat, Nadia, Hochegger, Helfrid and Doherty, Aidan J (2015) PrimPol-deficient cells exhibit a pronounced G2 checkpoint response following UV damage. Cell Cycle, 15 (7). pp. 908-918. ISSN 1538-4101

Jozwiakowski, Stanislaw K, Borazjani Gholami, Farimah and Doherty, Aidan J (2015) Archaeal replicative primases can perform translesion DNA synthesis. Proceedings of the National Academy of Sciences, 112 (7). E633-E638. ISSN 0027-8424

Guilliam, Thomas A, Jozwiakowski, Stanislaw K, Ehlinger, Aaron, Barnes, Ryan P, Rudd, Sean G, Bailey, Laura J, Skehel, J Mark, Eckert, Kristin A, Chazin, Walter J and Doherty, Aidan J (2015) Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins. Nucleic Acids Research, 43 (2). pp. 1056-1068. ISSN 0305-1048

Bartlett, Edward J, Brissett, Nigel C, Plocinski, Przemyslaw, Carlberg, Tom and Doherty, Aidan J (2015) Molecular basis for DNA strand displacement by NHEJ repair polymerases. Nucleic Acids Research. gkv965. ISSN 0305-1048

Guilliam, Thomas A, Keen, Benjamin A, Brissett, Nigel C and Doherty, Aidan J (2015) Primase-polymerases are a functionally diverse superfamily of replication and repair enzymes. Nucleic Acids Research, 43 (14). pp. 6651-6664. ISSN 0305-1048

Hentges, Pierre, Waller, Helen Rachel, Reis, Clara C, Ferreira, Miguel Godinho and Doherty, Aidan J (2014) Cdk1 restrains NHEJ through phosphorylation of XRCC4-like factor Xlf1. Cell Reports, 9 (6). pp. 2011-2017. ISSN 2211-1247

Jozwiakowski, Stanislaw A, Keith, Brian J, Gilroy, Louise, Doherty, Aidan J and Connolly, Bernard A (2014) An archaeal family-B DNA polymerase variant able to replicate past DNA damage: occurrence of replicative and translesion synthesis polymerases within the B family. Nucleic Acids Research, 42 (15). pp. 9949-9963. ISSN 0305-1048

Rasheduzzaman, Chowdhury, Brissett, Nigel, Krojer, Tobias, Ho, Chia-hua, Ng, Stanley S, Clifton, Ian J, Ge, Wei, Kershaw, Nadia J, Fox, Gavin C, Muniz, Joao R C, Vollmar, Melanie, Phillips, Claire, Pilka, Ewa S, Kavanagh, Kathryn L, von Delft, Frank, Oppermann, Udo, McDonough, Michael A, Doherty, Aidan and Schofield, Christopher J (2014) Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature, 510. pp. 422-426. ISSN 0028-0836

Kuron, Aneta, Korycka-Machala, Malgorzata, Brzostek, Anna, Nowosielski, Marcin, Doherty, Aidan, Dziadek, Bożena and Dziadek, Jaroslaw (2014) Evaluation of DNA primase DnaG as a potential target for antibiotics. Antimicrobial Agents and Chemotherapy, 58 (3). pp. 1699-1706. ISSN 1098-6596

Keen, Benjamin A, Bailey, Laura, Jozwiakowski, Stanislaw and Doherty, Aidan J (2014) Human PrimPol mutation associated with high myopia has a DNA replication defect. Nucleic Acids Research, 42 (19). pp. 12102-12111. ISSN 0305-1048

Keen, Benjamin A, Jozwiakowski, Stanislaw K, Bailey, Laura J, Bianchi, Julie and Doherty, Aidan J (2014) Molecular dissection of the domain architecture and catalytic activities of human PrimPol. Nucleic Acids Research, 42 (9). pp. 5830-5845. ISSN 0305-1048

Rudd, Sean G, Glover, Lucy, Jozwiakowski, Stanislaw K, Horn, David and Doherty, Aidan J (2013) PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the African trypanosome. Molecular Cell, 52 (4). pp. 554-565. ISSN 1097-2765

Bianchi, Julie, Rudd, Sean G, Jozwiakowski, Stanislaw K, Bailey, Laura J, Soura, Violetta, Taylor, Elaine, Stevanovic, Irena, Green, Andrew J, Stracker, Travis H, Lindsay, Howard D and Doherty, Aidan J (2013) PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replication. Molecular Cell, 52 (4). pp. 566-573. ISSN 1097-2765

Brissett, Nigel C, Martin, Maria J, Bartlett, Edward J, Bianchi, Julie, Blanco, Luis and Doherty, Aidan J (2013) Molecular basis for DNA double-strand break annealing and primer extension by a NHEJ DNA polymerase. Cell Reports, 5 (4). pp. 1108-1120. ISSN 2211-1247

Bartlett, Edward, Brissett, Nigel C and Doherty, Aidan J (2013) Ribonucleolytic resection is required for repair of strand displaced nonhomologous end-joining intermediates. Proceedings of the National Academy of Sciences, 110 (22). E1984-E1991. ISSN 1091-6490

Brissett, Nigel C, Martin, Maria J, Pitcher, Robert S, Bianchi, Julie, Juarez, Raquel, Green, Andrew J, Fox, Gavin C, Blanco, Luis and Doherty, Aidan J (2011) Structure of a preternary complex involving a prokaryotic NHEJ DNA polymerase. Molecular Cell, 41 (2). pp. 221-231. ISSN 1097-2765

Pitcher, R S, Brissett, N, Picher, A J, Andrade, P, Juarez, R, Thompson, D, Fox, G C, Blanco, L and Doherty, A J (2007) Structure and Function of a Mycobacterial NHEJ DNA Repair Polymerase. Journal of Molecular Biology, 366 (2). pp. 391-405. ISSN 0022-2836

Malyarchuk, Svitlana, Wright, Douglas, Castore, Reneau, Klepper, Emily, Weiss, Bernard, Doherty, Aidan J and Harrison, Lynn (2007) Expression of Mycobacterium tuberculosis Ku and Ligase D in Escherichia coli results in recA-independent DNA end-joining at regions of microhomology. DNA repair, 6 (10). pp. 1413-1424. ISSN 1568-7864

Pitcher, Robert S, Brissett, Nigel C and Doherty, Aidan J (2007) Nonhomologous end-joining in bacteria: a microbial perspective. Annual Review of Microbiology, 61. pp. 258-282. ISSN 0066-4227

Pitcher, Robert S, Tonkin, Louise M, Daley, James M, Palmbos, Phillip L, Green, Andrew, Velting, Tricia L, Brzostek, Anna, Korycka-Machala, Malgorzata, Cresawn, Steve, Dziadek, Jaroslaw, Hatfull, Graham F, Wilson, Thomas E and Doherty, Aidan J (2006) Mycobacteriophage exploit NHEJ to facilitate genome circularization. Molecular Cell, 23 (5). pp. 743-748. ISSN 1097-2765

Chavali, Gayatri B, Ekblad, Caroline M S, Basu, Balaka P, Brissett, Nigel C, Veprintsev, Dmitry, Hughes-Davies, Luke, Kouzarides, Tony, Itzhaki, Laura S and Doherty, Aidan J (2005) Crystal structure of the ENT domain of human EMSY. Journal of Molecular Biology, 350 (5). pp. 964-973. ISSN 0022-2836

Gissen, Paul, Johnson, Colin A, Gentle, Dean, Hurst, Laurence D, Doherty, Aidan J, O'Kane, Cahir J, Kelly, Deirdre A and Maher, Eamonn R (2005) Comparative evolutionary analysis of VPS33 homologues: genetic and functional insight. Human Molecular Genetics, 14 (10). pp. 1261-1270. ISSN 0964-6906

Della, Marina, Palmbos, Phillip L, Tseng, Hui-Min, Tonkin, Louise M, Daley, James M, Topper, Leana M, Pitcher, Robert S, Tomkinson, Alan E, Wilson, Thomas E and Doherty, Aidan J (2004) Mycobacterial Ku and ligase proteins constitute a two-component NHEJ repair machine. Science, 306 (5696). pp. 683-685. ISSN 0036-8075

Girard, Pierre-Marie, Kysela, Boris, Härer, Christine J, Doherty, Aidan J and Jeggo, Penny A (2004) Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: the impact of two linked polymorphisms. Human Molecular Genetics, 13 (20). pp. 2369-2376. ISSN 0964-6906

Iwabuchi, Kuniyoshi, Basu, Balaka Piku, Kysela, Boris, Kurihara, Takayuki, Shibata, Masao, Guan, Deyu, Cao, Yongheng, Hamada, Tomio, Imamura, Kouji, Jeggo, Penny A, Date, Takayasu and Doherty, Aidan J (2003) Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA. Journal of Biological Chemistry, 278 (38). pp. 36487-36495. ISSN 0021-9258

Weller, Geoffery R, Kysela, Boris, Roy, Rajat, Tonkin, Louise M, Scanlan, Elizabeth, Della, Marina, Devine, Susanne Krogh, Day, Jonathan P, Wilkinson, Adam, d'Adda di Fagagna, Fabrizio, Devine, Kevin M, Bowater, Richard P, Jeggo, Penny A, Jackson, Stephen P and Doherty, Aidan J (2002) Identification of a DNA nonhomologous end-joining complex in bacteria. Science, 297. pp. 1686-1689. ISSN 0036-8075