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Frances Pearl
Bioinformatics Academic Research Manager (Biochemistry)
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T: +44 (0)1273 876631

Selected publications

Article

Glusman, Gustavo, Rose, Peter W, Prlić, Andrea, Dougherty, Jennifer, Duarte, José M, Hoffmann, Andrew S, Barton, Geoffery J, Bendixen, Emøke, Bergquist, Timothy, Bock, Christian, Brunk, Elizabeth, Buljan, Marija, Burley, Stephen K, Cai, Binguang, Carter, Hannah, Gao, JiangJong, Godzik, Adam, Heuer, Michael, Hicks, Michael, Hrabe, Thomas, Karchin, Rachel, Kohler Leman, Julia, Lane, Lydie, Masica, David L, Mooney, Sean D, Moult, John, Omenn, Gilbert S, Pearl, Frances, Pejavar, Vikas, Reynolds, Sheila M, Rokem, Ariel, Schwede, Torsten, Song, Sicheng, Tilger, Hagen, Valasatava, Yana, Zhang, Yang and Deutsch, Eric W (2018) Mapping genetic variations to three- dimensional protein structures to enhance variant interpretation: a proposed framework. Genome Medicine, 9 (113). pp. 1-10. ISSN 1756-994X

Benstead-Hume, Graeme, Wooller, Sarah and Pearl, Frances M G (2017) Computational approaches to identify genetic interactions for cancer therapeutics. Journal of Intergrative Bioinformatics, 14 (3). pp. 1-12. ISSN 1613-4516

Wooller, Sarah K, Benstead-Hume, Graeme, Chen, Xiangrong, Ali, Yusuf and Pearl, Frances MG (2017) Bioinformatics in translational drug discovery. Biosience Reports, 37 (4). pp. 1-13. ISSN 0144-8463

Benstead-Hume, Graeme, Wooller, Sarah K and Pearl, Frances M G (2017) 'Big data' approaches for novel anti-cancer drug discovery. Expert opinion in drug discovery, 12 (6). pp. 599-609. ISSN 1746-045X

Baeissa, Hanadi, Benstead-Hume, Graeme, Richardson, Christopher J and Pearl, Frances M G (2017) Identification and analysis of mutational hotspots in oncogenes and tumour suppressors. Oncotarget, 8 (13). pp. 21290-21304. ISSN 1949-2553

Ocasio, Cory A, Rajasekaran, Mohan B, Walker, Sarah, Le Grand, Darren, Spencer, John, Pearl, Frances M G, Ward, Simon E, Savic, Velibor, Pearl, Laurence H, Hochegger, Helfrid and Oliver, Antony W (2016) A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct. Oncotarget, 7 (44). 71182 -71197. ISSN 1949-2553

Baeissa, Hanadi M, Benstead-Hume, Graeme, Richardson, Christopher J and Pearl, Frances M G (2016) Mutational patterns in oncogenes and tumour suppressors. Biochemical Society Transactions, 44 (3). pp. 952-931. ISSN 0300-5127

Peña-Oliver, Yolanda, Carvalho, Fabiana M, Sanchez-Roige, Sandra, Quinlan, Erin B, Jia, Tianye, Walker-Tilley, Tom, Rulten, Stuart L, Pearl, Frances M G, Banaschewski, Tobias, Barker, Gareth J, Bokde, Arun L W, Büchel, Christian, Conrod, Patricia J, Flor, Herta, Gallinat, Jürgen, Garavan, Hugh, Heinz, Andreas, Gowland, Penny, Paillere Martinot, Marie-Laure, Paus, Tomáš, Rietschel, Marcella, Robbins, Trevor W, Smolka, Michael N, Schumann, Gunter, Stephens, David N and for the IMAGEN Consortium, (2016) Mouse and human genetic analyses associate kalirin with ventral striatal activation during impulsivity and with alcohol misuse. Frontiers in Genetics, 7. a52. ISSN 1664-8021

Pearl, Laurence H, Schierz, Amanda C, Ward, Simon E, Al-Lazikani, Bissan and Pearl, Frances M G (2015) Therapeutic opportunities within the DNA damage response. Nature Reviews Cancer, 15. pp. 166-180. ISSN 1474-175X

Mengozzi, Manuela, Ermilov, Peter, Annenkov, Alexander, Ghezzi, Pietro and Pearl, Frances (2014) Definition of a family of tissue-protective cytokines using functional cluster analysis: a proof-of-concept study. Frontiers in immunology, 5 (115). pp. 1-7. ISSN 1664-3224

Espinosa, Octavio, Mitsopoulos, Konstantinos, Hakas, Jarle, Pearl, Frances and Zvelebil, Marketa (2014) Deriving a mutation index of carcinogenicity using protein structure and protein interfaces. PLoS ONE, 9 (1). e84598. ISSN 1932-6203

Magny, Emile G, Pueyo-Marques, Jose, Pearl, Frances M G, Cespedes, Miguel Angel, Niven, Jeremy E, Bishop, Sarah A and Couso, Juan Pablo (2013) Conserved regulation of cardiac calcium uptake by peptides encoded in small open reading frames. Science, 341. pp. 1116-1120. ISSN 0036-8075

Cuff, Alison, Redfern, Oliver C, Greene, Lesley, Sillitoe, Ian, Lewis, Tony, Dibley, Mark, Reid, Adam, Pearl, Frances, Dallman, Tim, Todd, Annabel, Garratt, Richard, Thornton, Janet and Orengo, Christine (2009) The CATH hierarchy revisited structural divergence in domain superfamilies and the continuity of fold space. Structure, 17 (8). pp. 1051-62. ISSN 0969-2126

Richardson, Christopher J, Gao, Qiong, Mitsopoulous, Costas, Zvelebil, Marketa, Pearl, Laurence H and Pearl, Frances M G (2009) MoKCa database - mutations of kinases in cancer. Nucleic Acids Research, 37 (S1). D824-D831. ISSN 0305-1048

Redfern, Oliver C, Harrison, Andrew, Dallman, Tim, Pearl, Frances M G and Orengo, Christine A (2007) CATHEDRAL: A Fast and Effective Algorithm to Predict Folds and Domain Boundaries from Multidomain Protein Structures. PLoS Computational Biology, 3 (11). e232. ISSN 1553-734X

Greene, Lesley H, Lewis, Tony E, Addou, Sarah, Cuff, Alison, Dallman, Tim, Dibley, Mark, Redfern, Oliver, Pearl, Frances, Nambudiry, Rekha, Reid, Adam, Sillitoe, Ian, Yeats, Corin, Thornton, Janet M and Orengo, Christine A (2007) The CATH domain structure database: new protocols and classification levels give a more comprehensive resource for exploring evolution. Nucleic Acids Research, 35 (DI). D291-D297. ISSN 0305-1048

Pearl, Frances, Todd, Annabel, Sillitoe, Ian, Dibley, Mark, Redfern, Oliver, Lewis, Tony, Bennett, Christopher, Marsden, Russell, Grant, Alistair, Lee, David, Akpor, Adrian, Maibaum, Michael, Harrison, Andrew, Dallman, Timothy, Reeves, Gabrielle, Diboun, Ilhem, Addou, Sarah, Lise, Stefano, Johnston, Caroline, Sillero, Antonio, Thornton, Janet and Orengo, Christine (2005) The CATH Domain Structure Database and related resources Gene3D and DHS provide comprehensive domain family information for genome analysis. Nucleic Acids Research, 33 (S1). D247-D251. ISSN 0305-1048