|Post:||Bioinformatics Academic Research Manager (Biochemistry)|
|Other posts:||Associate Tutor (Life Sciences)|
|Facility Manager (Biochemistry)|
|Location:||Chichester 2 2r316|
|International:||+44 1273 876631|
|download vCarddownload vCard to your mobile|
- BSc Chemistry, 1st Class. UMIST
- PhD, University College London (Dame Janet Thornton FRS) Analysis of alpha helices and their interactions.
After my PhD I spent 7 years as the CATH database manager at UCL. The CATH database classifies protein structural domains into structural and evolutionary families. I ran the CATH update team and developed algorithms to maintain the CATH database.
Following a career break, I was awarded a Daphne Jackson Research Fellowship hosted at ICR and funded by the MRC, to develop the MoKCa database that analyses cancer associated mutations.
Bioinformatics Academic Research Manager
My role as as Bioinformatics Academic Research Manager is to develop bioinformatic collaborations with the School of Life Sciences. For instance, to support actvities in the Translational Drug Discovery Group at Sussex we have established computational biology and chemistry protocols to support the effective design of novel chemical modulators. Cheminformatic protocols have been designed for activities such as compound library selection, virtual screening, scaffold hopping and rational drug design. We also have an established expertise in protein modelling and and small molecule docking.
For further information on our research, please see the Bioinformatics Lab Web Pages
Research interests include:
- Analysing protein sequence and structure data to analyse the evolution of protein families.
- Analysis of the functional consequences of cancer associated mutations.
- Integrating bio and cheminformatics data to support the drug discovery process.
For further information on our research, please see the Bioinformatics web page
- Genomics and Bioinformatics (Year 3)
Lectures &/or Computer Workshops:
- Protein Form and Function (Year 3)
- Genomics and Bioinformatics (Year 3)
- Structural Basis for Biological Function (Year 2)
- Genetics and Genomics (Year 2)
- Advanced Methods in Molecular Research (MSc)
Magny, Emile G, Pueyo-Marques, Jose, Pearl, Frances M G, Cespedes, Miguel Angel, Niven, Jeremy E, Bishop, Sarah A and Couso, Juan Pablo (2013) Conserved regulation of cardiac calcium uptake by peptides encoded in small open reading frames. Science, 341. pp. 1116-1120. ISSN 0036-8075
Cuff, Alison, Redfern, Oliver C, Greene, Lesley, Sillitoe, Ian, Lewis, Tony, Dibley, Mark, Reid, Adam, Pearl, Frances, Dallman, Tim, Todd, Annabel, Garratt, Richard, Thornton, Janet and Orengo, Christine (2009) The CATH hierarchy revisited structural divergence in domain superfamilies and the continuity of fold space. Structure, 17 (8). pp. 1051-62. ISSN 0969-2126
Richardson, Christopher J, Gao, Qiong, Mitsopoulous, Costas, Zvelebil, Marketa, Pearl, Laurence H and Pearl, Frances M G (2009) MoKCa database - mutations of kinases in cancer. Nucleic Acids Research, 37 (S1). D824-D831. ISSN 0305-1048
Redfern, Oliver C, Harrison, Andrew, Dallman, Tim, Pearl, Frances M G and Orengo, Christine A (2007) CATHEDRAL: A Fast and Effective Algorithm to Predict Folds and Domain Boundaries from Multidomain Protein Structures. PLoS Computational Biology, 3 (11). e232. ISSN 1553-734X
Greene, Lesley H, Lewis, Tony E, Addou, Sarah, Cuff, Alison, Dallman, Tim, Dibley, Mark, Redfern, Oliver, Pearl, Frances, Nambudiry, Rekha, Reid, Adam, Sillitoe, Ian, Yeats, Corin, Thornton, Janet M and Orengo, Christine A (2007) The CATH domain structure database: new protocols and classification levels give a more comprehensive resource for exploring evolution. Nucleic Acids Research, 35 (DI). D291-D297. ISSN 0305-1048
Pearl, Frances, Todd, Annabel, Sillitoe, Ian, Dibley, Mark, Redfern, Oliver, Lewis, Tony, Bennett, Christopher, Marsden, Russell, Grant, Alistair, Lee, David, Akpor, Adrian, Maibaum, Michael, Harrison, Andrew, Dallman, Timothy, Reeves, Gabrielle, Diboun, Ilhem, Addou, Sarah, Lise, Stefano, Johnston, Caroline, Sillero, Antonio, Thornton, Janet and Orengo, Christine (2005) The CATH Domain Structure Database and related resources Gene3D and DHS provide comprehensive domain family information for genome analysis. Nucleic Acids Research, 33 (S1). D247-D251. ISSN 0305-1048
- Email for an appointment