Photo of Keith Caldecott

Keith Caldecott
Professor of Biochemistry 'Royal Society Wolfson Research Merit Award Holder' (Genome Damage and Stability)
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T: +44 (0)1273 877519 or +44 (0)1273 877511


Selected publications

Article

Zeng, Zhihong, Rulten, Stuart L, Breslin, Claire, Zlatanou, Anastasia, Coulthard, Victoria and Caldecott, Keith (2017) Acylpeptide hydrolase is a component of the cellular response to DNA damage. DNA Repair, 58. pp. 52-61. ISSN 1568-7864

Breslin, Claire, Mani, Rajam S, Fanta, Mesfin, Hoch, Nicolas, Weinfield, Michael and Caldecott, Keith W (2017) The RIR motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair. Journal of Biological Chemistry, 292. pp. 16024-16031. ISSN 1083-351X

Gómez-Herreros, Fernando, Zagnoli-Vieira, Guido, Ntai, Ioanna, Martínez-Macías, María Isabel, Anderson, Rhona M, Herrero-Ruíz, Andrés and Caldecott, Keith (2017) TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription. Nature Communications, 8 (233). ISSN 2041-1723

Hanzlikova, Hana, Gittens, William, Krejcikova, Katerina, Zeng, Zhihong and Caldecott, Keith W (2017) Overlapping roles for PARP1 and PARP2 in the recruitment of endogenous XRCC1 and PNKP into oxidized chromatin. Nucleic Acids Research, 45 (5). pp. 2546-2557. ISSN 1362-4962

Hoch, Nicolas C, Hanzlikova, Hana, Rulten, Stuart L, Tétreault, Martine, Komulainen, Emilia, Ju, Limei, Hornyak, Peter, Zeng, Zhihong, Gittens, William, Rey, Stephanie A, Staras, Kevin, Mancini, Grazia M S, McKinnon, Peter J, Wang, Zhao-Qi, Wagner, Justin, Yoon, Grace and Caldecott, Keith W (2016) XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia. Nature, 541 (7635). pp. 87-91. ISSN 0028-0836

Grundy, Gabrielle J, Polo, Luis M, Zeng, Zhihong, Rulten, Stuart, Hoch, Nicolas, Pathompong, Paomephan, Xu, Yingqi, Sweet, Steve M, Thorne, Alan W, Oliver, Antony W, Matthews, Steve J, Pearl, Laurence H and Caldecott, Keith W (2016) PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2). Nature Communications, 7 (12404). ISSN 2041-1723

Grundy, Gabrielle J, Rulten, Stuart L, Arribas-Bosacoma, Raquel, Davidson, Kathryn, Kozik, Zuzanna, Oliver, Antony W, Pearl, Laurence H and Caldecott, Keith W (2016) The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins. Nature Communications, 7. a11242. ISSN 2041-1723

Breslin, Claire, Hornyak, Peter, Ridley, Andrew, Rulten, Stuart L, Hanzlikova, Hana, Oliver, Antony W and Caldecott, Keith W (2015) The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function. Nucleic Acids Research, 43 (14). pp. 6934-6944. ISSN 0305-1048

Gomez Herreros, Fernando, Schuurs-Hoeijmakers, Janneke H M, McCormack, Mark, Greally, Marie T, Rulten, Stuart, Romero-Granados, Rocio, Counihan, Timothy J, Chaila, Elijah, Conroy, Judith, Ennis, Sean, Delanty, Norman, Cortes-Ledesma, Felipe, de Brouwer, Arjan P M, Cavalleri, Gianpiero L, El-Khamisy, Sherif F, de Vries, Bert B A and Caldecott, Keith (2014) TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function. Nature Genetics, 46 (5). pp. 516-524. ISSN 1061-4036

Grundy, Gabrielle L, Rulten, Stuart L, Zeng, Zhihong, Arribas-Bosacoma, Raquel, Iles, Natasha, Manley, Katie, Oliver, Antony and Caldecott, Keith W (2013) APLF promotes the assembly and activity of non-homologous end joining protein complexes. The EMBO journal, 32 (1). pp. 112-125. ISSN 1460-2075

Reynolds, John J, Walker, Alexandra K, Gilmore, Edward C, Walsh, Christopher A and Caldecott, Keith W (2012) Impact of PNKP mutations associated with microcephaly, seizures and developmental delay on enzyme activity and DNA strand break repair. Nucleic Acids Research. ISSN 1362-4962

Rulten, Stuart L, Fisher, Anna E O, Robert, Isabelle, Zuma, Maria C, Rouleau, Michele, Ju, Limei, Poirier, Guy, Reina-San-Martin, Bernardo and Caldecott, Keith W (2011) PARP-3 and APLF function together to accelerate nonhomologous end joining. Molecular Cell, 41 (1). pp. 33-45. ISSN 1097-2765

Zeng, Zhihong, Cortés-Ledesma, Felipe, El-Khamisy, Sherif F and Caldecott, Keith W (2010) TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage. Journal of Biological Chemistry, 286 (1). pp. 403-409. ISSN 0021-9258

Shen, Jun, Gilmore, Edward C, Marshall, Christine A, Haddadin, Mary, Reynolds, John J, Eyaid, Wafaa, Bodell, Adria, Barry, Brenda, Gleason, Danielle, Allen, Kathryn, Ganesh, Vijay S, Chang, Bernard S, Grix, Arthur, Hill, R Sean, Topcu, Meral, Caldecott, Keith W, Barkovich, A James and Walsh, Christopher A (2010) Mutations in PNKP cause microcephaly, seizures and defects in DNA repair. Nature Genetics, 42 (3). 245-U38. ISSN 1061-4036

Cortes Ledesma, Felipe, El-Khamisy, Sherif F, Zuma, Maria C, Osborn, Kay and Caldecott, Keith W (2009) A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage. Nature, 461 (7264). pp. 674-678. ISSN 0028-0836

Lee, Youngsoo, Katyal, Sachin, Li, Yang, El-Khamisy, Sherif F, Russell, Helen R, Caldecott, Keith W and McKinnon, Peter J (2009) The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1. Nature Neuroscience, 12 (8). 973-U35. ISSN 1097-6256

Caldecott, Keith (2008) Single-strand break repair and genetic disease. Nature Reviews Genetics, 9 (8). pp. 619-631. ISSN 0028-0836

Katyal, Sachin, El-Khamisy, Sherif F, Russell, Helen R, Liu, Yang, Ju, Limei, Caldecott, Keith W and McKinnon, Peter J (2007) TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo. EMBO Journal, 26. pp. 4720-4731. ISSN 0261-4189

Ahel, Ivan, Rass, Ulrich, El-Khamisy, Sherif F, Katyal, Sachin, Clements, Paula M, McKinnon, Peter J, Caldecott, Keith W and West, Stephen C (2006) The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature, 443. pp. 713-716. ISSN 0028-0836

Breslin, Claire, Clements, Paula M, El-Khamisy, Sherif F, Petermann, Eva, Iles, Natasha and Caldecott, Keith W (2006) Measurement of chromosomal DNA single-strand breaks and replication fork progression rates. Methods in Enzymology, 409. pp. 410-425. ISSN 0076-6879

El-Khamisy, Sherif F, Saifi, Gulam M, Weinfeld, Michael, Johansson, Fredrik, Helleday, Thomas, Lupski, James R and Caldecott, Keith W (2005) Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1. Nature, 434. pp. 108-113. ISSN 0028-0836

Loizou, Joanna I, El-Khamisy, Sherif F, Zlatanou, Anastasia, Moore, David J, Chan, Douglas W, Qin, Jun, Sarno, Stefania, Meggio, Flavio, Pinna, Lorenzo A and Caldecott, Keith W (2004) The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks. Cell, 117 (1). pp. 17-28. ISSN 0092-8674

Henry-Mowatt, Judith, Jackson, Dean, Masson, Jean-Yves, Johnson, Penny A, Clements, Paula M, Benson, Fiona E, Thompson, Larry H, Takeda, Shunichi, West, Stephen C and Caldecott, Keith W (2003) XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes. Molecular Cell, 11 (4). pp. 1109-1117. ISSN 1097-2765

Whitehouse, Claire J, Taylor, Richard M, Thistlethwaite, Angela, Zhang, Hong, Karimi-Busheri, Feridoun, Lasko, Dana D, Weinfeld, Michael and Caldecott, Keith W (2001) XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair. Cell, 104 (1). pp. 107-117. ISSN 0092-8674