photo of Keith Caldecott

Prof Keith Caldecott

Post:Professor of Biochemistry 'Royal Society Wolfson Research Merit Award Holder' (Genome Damage and Stability)
Other posts:Royal Society Wolfson Research Merit Award Holder (Genome Damage and Stability Centre)
Location:GENOME CENTRE G3.04

Telephone numbers
UK:01273 678482
International:+44 1273 678482

Research expertise:
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Keith Caldecott obtained his BSc (Hons) at Sheffield Unversity (1987) and developed an interest in how cells repair DNA strand breaks during his PhD in the laboratory of Penny Jeggo, at the Medical Research Council’s National Institute for Medical Research (London). Keith's interest in DNA repair continued during postdoctoral fellowships with Larry Thompson (California) and Tomas Lindahl FRS (London), and in 1995 Keith established his own laboratory at the University of Manchester. In 2002 the Caldecott lab moved to the Genome Damage and Stability Centre (GDSC); a multi-disciplinary centre-of-excellence funded jointly by the MRC and the University of Sussex. Highlights from the Caldecott laboratory, to date, include establishing that the dual function DNA kinase/DNA phosphatase enzyme PNKP works in concert with XRCC1 during DNA single-strand break repair (Whitehouse et al, Cell 2001), that the protein kinase CK2 is a bona fide DNA damage response protein (Loizou et al, Cell, 2004), and that specific hereditary neurodegenerative diseases are associated with cellular defects in chromosomal SSBR (El Khamisy et al, Nature, 2005; Shen et al, Nature Genetics 2010). The Caldecott laboratory also recently identified the first 5’-tyrosyl DNA phosphodiesterase activity (TDP2) in human cells (Cortes-Ledesma et al, Nature 2009), identified poly (ADP-ribose) polymerase-3 (PARP3) as a novel component of the repair of DNA double-strand breaks (Rulten et al, Mol Cell, 2011), and associated the loss of TDP2 with transcriptional dysfunction and human neurodegenerative disease (Gomes-Herreros, Nature Genetics 2014). In 2010 Keith was elected a member of EMBO, and in 2012 was elected a member of the Academy of Medical Sciences (FMedSci).

Please see the Caldecott lab home page for more detail ( 


Deputy Director of the Genome Damage and Stability Centre 

Community and Business

Keith Caldecott was a member of the CR-UK Biological Sciences Committee (2008-2011) and is currently a member of the MRC Molecular and Cellular Medicine Board