Selected publications

Article

Benstead-Hume, Graeme, Wooller, Sarah, Renault, Joanna, Dias, Samantha, Woodbine, Lisa, Carr, Tony and Pearl, Frances (2022) Biological network topology features predict gene dependencies in cancer cell-lines. Bioinformatics Advances. vbac084 1-8. ISSN 2635-0041

Schiavoni, Federica, Zuazua-Villar, Pedro, Roumeliotis, Theodoros I, Benstead-Hume, Graeme, Pardo, Mercedes, Pearl, Francis M G, Choudhary, Jyoti S and Downs, Jessica A (2022) Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness. Nature Communications, 13. pp. 1-15. ISSN 2041-1723

Gagliano, Teresa, Shah, Kalpit, Gargani, Sofia, Lao, Liyan, Alsaleem, Mansour, Chen, Jianing, Ntafis, Vasileios, Huang, Penghan, Ditsiou, Angeliki, Vella, Viviana, Yadav, Kritika, Bienkowska, Kamila, Benstead-Hum, Graeme, Pearl, Frances M G, Giamas, Georgios and others, (2020) PIK3Cδ expression by fibroblasts promotes triple-negative breast cancer progression. Journal of Clinical Investigation, 130 (6). pp. 3188-3204. ISSN 0021-9738

Benstead-Hume, Graeme, Wooller, Sarah, Downs, Jessica and Pearl, Frances (2019) Defining signatures of arm-wise copy number change and their associated drivers in kidney cancers. International Journal of Molecular Sciences, 20 (22). a5762. ISSN 1661-6596

Lane, Rosemary, Simon, Thomas, Vintu, Marian, Solkin, Benjamin, Koch, Barbara, Stewart, Nicolas, Benstead-Hume, Graeme, Pearl, Frances M G, Critchley, Giles, Stebbing, Justin and Giamas, Georgios (2019) Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping. Communications Biology, 2. a315. ISSN 2399-3642

Benstead-Hume, Graeme, Chen, Xiangrong, Hopkins, Suzi, Lane, Karen A, Downs, Jessica and Pearl, Frances M G (2019) Predicting synthetic lethal interactions using conserved patterns in protein interaction networks. PLoS Computational Biology, 15 (4). e1006888. ISSN 1553-7358

Meisenberg, Cornelia, Pinder, Sarah I, Hopkins, Suzanna R, Wooller, Sarah K, Benstead-Hume, Graeme, Pearl, Frances M G, Jeggo, Penny A and Downs, Jessica A (2019) Repression of transcription at DNA breaks requires cohesin throughout interphase and prevents genome instability. Molecular Cell, 73 (2). 212-223.e7. ISSN 1097-2765

Benstead-Hume, Graeme, Wooller, Sarah and Pearl, Frances M G (2017) Computational approaches to identify genetic interactions for cancer therapeutics. Journal of Intergrative Bioinformatics, 14 (3). pp. 1-12. ISSN 1613-4516

Wooller, Sarah K, Benstead-Hume, Graeme, Chen, Xiangrong, Ali, Yusuf and Pearl, Frances MG (2017) Bioinformatics in translational drug discovery. Bioscience Reports, 37 (4). pp. 1-13. ISSN 0144-8463

Benstead-Hume, Graeme, Wooller, Sarah K and Pearl, Frances M G (2017) 'Big data' approaches for novel anti-cancer drug discovery. Expert opinion in drug discovery, 12 (6). pp. 599-609. ISSN 1746-045X

Baeissa, Hanadi, Benstead-Hume, Graeme, Richardson, Christopher J and Pearl, Frances M G (2017) Identification and analysis of mutational hotspots in oncogenes and tumour suppressors. Oncotarget, 8 (13). pp. 21290-21304. ISSN 1949-2553

Thesis

Benstead-Hume, Graeme (2019) Exploiting patterns in genomic data for personalised cancer treatment and new target discovery. Doctoral thesis (PhD), University of Sussex.