Genome Stability, Genetic Diseases and Cancer (C7129)

15 credits, Level 6

Spring teaching

The design of new therapies for cancer depends on first understanding the molecular events that cause the disease. Genomic DNA is damaged spontaneously, by chemical carcinogens and by radiation. If unrepaired, this damage leads to mutations, cancer and other developmental disorders. All cells have evolved a sophisticated array of repair and response mechanisms to deal with DNA damage.

In this module, you aim to understand the molecular mechanisms that control DNA repair and appreciate how defects in genes involved in these repair processes are associated with different, in many cases cancer-prone, genetic disorders.

You will review and critically evaluate recently published experimental evidence, as advances in this area rely on a combination of biochemical analysis, genetic approaches and bioinformatics.

Teaching

76%: Lecture
24%: Seminar (Class, Seminar)

Assessment

30%: Coursework (Test)
70%: Examination (Unseen examination)

Contact hours and workload

This module is 150 hours of work. This breaks down into 29 hours of contact time and 121 hours of independent study.

This module is running in the academic year 2018/19. We also plan to offer it in future academic years. It may become unavailable due to staff availability, student demand or updates to our curriculum. We’ll make sure to let our applicants know of such changes to modules at the earliest opportunity.

Courses

This module is offered on the following courses: