Research highlights in Pharmacy include:

Buge Apampa, Pharmacy Practice and Education

My research interests include:

  • Pharmaceutical care
  • Medication safety and
  • Pharmacy education

My primary interest lies in the development and evaluation of pharmaceutical care models with an emphasis on how non-medical healthcare professionals including community pharmacists, can optimize medicines usage for people with long-term conditions. We are currently researching into the nature and quality of services provided by community pharmacists to patients living with dementia in care homes, with a view to re-engineering the current service model into an enhanced cognitive service.  

 

Brian Cox,  Pharmaceutical Chemistry

My research interests include:

  • The prosecution of novel hit and lead optimization programs in a number of therapeutic areas (Respiratory, Neuroscience and developing world diseases).
  • The use of high throughput automated chemistry for hit and lead optimization and the generation of new compound libraries with drug-like properties in novel chemical space.
  • The development of novel chemistries for use on high throughput automated synthesis platforms.

The high throughput chemistry facility has been designed and set up to industry standard. The group collaborates both internally and externally. Internally it is involved in a number of drug discovery initiatives within Life Sciences. Externally, it has major involvements in a joint university company start-up project (Photodiversity Ltd) with the University of Bristol (Professor Kevin Booker-Milburn), with the University of Genève looking at new treatments for Chagas disease (American trypanosomiasis) and with a number of pharmaceutical companies globally.

 

Tara Ghafourian, Pharmaceutics and Drug Delivery

 My research interests include: 

  • Cheminformatics and QSAR Research
  • Prediction of substrates and inhibitors of various transporter proteins, including multidrug resistance proteins
  • ADME properties such as permeability, solubility and oral absorption of compounds, their volume of distribution, and biliary excretion
  • Prediction of adverse drug reactions
  • Effect of pharmacological interventions on ageing

 Cheminformatics and QSAR research aim to develop models for the prediction of biological properties of compounds including (but not limited to) drugs and drug candidates. These models are used as in silico screening tools for the prediction of drug properties such as their oral and skin absorption, tissue distribution, protein binding, metabolism, and pharmacological and toxicological profiles. We use molecular modelling, docking, and data mining of large datasets to develop predictive models aided by computer software.

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Martin Gosling,  Molecular Pharmacology

My research interests include: 

  • The discovery of novel therapeutics for the treatment of respiratory and neurological diseases.
  • Defining the physiological and pathophysiological roles of ion channels and their subsequent prosecution as therapeutic targets for drug discovery.
  • Using novel screening approaches to identify novel chemical probes and biological drug targets.

 As part of the Sussex Drug Discovery Centre my research is focussed upon novel translational drug discovery and the delivery of new drugs for diseases of high unmet medical need. Our group has core capabilities in ion channel pharmacology including medium throughput screening and both conventional and automated electrophysiology. In collaboration with other Sussex Drug Discovery faculty members and external pharmaceutical and biotech companies we have active drug discovery programs aimed at treating anxiety, schizophrenia, migraine and cystic fibrosis.

 

Geeta Hitch, Pharmacy Practice

 My research interests include:

  • Pharmacy Education and Learning Technology
  • Bacteriophages as novel antimicrobial therapeutic agents.

 I am part of the team that recently won the Technology Enhanced Learning award to develop  e-learning packages using Articulate Storyline 2 in conjunction with SimMan 3G- a high fidelity computerised human patient simulator.  Simulation of clinical practice in a risk free, controlled environment enables students to acquire knowledge and understanding and the clinical skills that underpin the safe use of medicines.

Ali Nokhodchi, Pharmaceutics and Drug Delivery

 My research interests include:

  • Development of Novel Methods and Technologies for design of dosage forms for systemic and targeted delivery of drugs (both small and large molecules).
  • Particle engineering for oral and pulmonary delivery of drugs
  • Controlled release formulation design
  • Biopharmaceutical aspects of drug delivery.

In the pharmaceutics research laboratory, our research involves exploring the physicochemical properties of drugs and excipients for efficient dosage form design, and the manufacture of these dosage forms on a small scale. The laboratory has excellent research facilities and equipment which include an extruder, spheronizer, coater, tablet machine, granulator, spray dryer, laser particle size analyser, automatic dissolution testers (USP I, II and biodissolution), ball mill, turbula blender, viscometer, air jet sieve. We also have access to cell culture facilities, SEM and a full range of high end analytical instrumentation in the School of Life Sciences.  The pharmaceutics research laboratory collaborates with several pharmaceutical industrial and manufacturing units both within the UK and internationally.

Mike Pettit,  Pharmacy Practice

  My research interests include:  

  • Medication safety and improving prescribing for paediatric patients and neonates
  • Clinical pharmacokinetics
  • Standard setting in assessments

The use of medication is not without risk. Modern medicines, while effective, can have side effects. Selecting the appropriate medicine and formulation, with clarity in prescribing is essential to maximise benefits and minimise risks. The use of global risk scores, identifying high-risk medicines and regular audits of prescribing and outcomes can aid effective prescribing. The use of validated prescribing tools, such as those which eliminate dose calculation error or utilise therapeutic drug monitoring data benefits patient safety.

 

Jane Portlock, Pharmacy Education and Professionalism

My research interests include:

  • Pharmacy professional role development in the UK and internationally
  • Pharmacy education enhancement and evaluation

My current research is focussed on the development of the pharmacy professional for the benefit of patients and includes the following PhD research projects – development of the Healthy Living Pharmacy works to deliver benefits in health promotion, clinical pharmacy role development in Kuwait (public health roles in cardiovascular disease risk minimisation) and Saudi Arabia (medicines safety). My research with an educational theme includes the following PhD projects – development and evaluation of a “flipped classroom” approach for teaching therapeutics, evaluation of the use of simulation and “immersive” approaches to education with the pharmacy undergraduate curriculum, investigation of the impact of peer mentors and peer assisted learning for undergraduates, development and teaching of professionalism for undergraduates and in early professional practice.

 

Collaborations

Sussex Pharmacy collaborates with the following groups, centres and Schools

Sussex Drug Discovery Centre