| Post: | Professor of Molecular Genetics |
| Other posts: | Professor of Molecular Genetics (Biochemistry) |
| Location: | Genome Centre G4.08 |
| Email: | A.R.Lehmann@sussex.ac.uk |
| Telephone numbers | |
| Internal: | 8120 or 7170 |
| UK: | (01273) 678120 or (01273) 877170 |
| International: | +44 1273 678120 or +44 1273 877170 |
Biography
Background:
BA PhD (London)
Key responsibilities:
Course organiser: Genome stability, genetic diseases and cancer
Chairman: Genome damage and stability centre
Research
1. Replication of damaged DNA. Y-family DNA polymerases and relation to human disorders.
2. Genetic disorders with defects in DNA repair and transcription: Xeroderma pigmentosum, Cockayne Syndrome and trichothiodystrophy.
3. SMC protein involved in DNA repair in yeast and man.
For further information, see Genome Damage and Stability web-page
Publications
1. Ogi, T., and Lehmann, A. R. (2006).
The Y-family DNA polymerase kappa (pol kappa) functions in mammalian nucleotide-excision repair.
Nat Cell Biol 8, 640-642.
2. Palecek, J., Vidot, S., Feng, M., Doherty, A. J., and Lehmann, A. R. (2006)
The SMC5-6 DNA repair complex: Bridging of the SMC5-6 heads by the Kleisin, NSE4, and non-Kleisin subunits. J Biol Chem 281, 36952-36959
3. Bienko, M., Green, C. M., Crosetto, N., Rudolf, F., Zapart, G., Coull, B., Kannouche, P., Wider, G., Peter, M., Lehmann, A. R., et al. (2005).
Ubiquitin-binding domains in translesion synthesis polymerases.
Science 310, 1821-1824.
4. Friedberg, E. C., Lehmann, A. R., and Fuchs, R. P. (2005).
Trading places: how do DNA polymerases switch during translesion DNA synthesis?
Mol Cell 18, 499-505Domain structure, localization and function of DNA polymerase ç, defective in xeroderma pigmentosum variant cells.
Genes Dev. 15, 158-172
5. Sergeant, J., Taylor, E., Palecek, J., Fousteri, M., Andrews, E., Sweeney, S., Shinagawa, H., Watts, F. Z., and Lehmann, A. R. (2005).
Composition and architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) complex.
Mol Cell Biol 25, 172-184.
6. Kannouche, P. L., Wing, J., and Lehmann, A. R. (2004).
Interaction of Human DNA Polymerase h with Monoubiquitinated PCNA; A Possible Mechanism for the Polymerase Switch in Response to DNA Damage.
Mol Cell 14, 491-500.