Research Fellow in Chemical Biology/Medicinal Chemistry

School/department: School of Life Sciences
Hours: full time
Contract: fixed term for 2 years
Reference:  2758
Salary: starting at £32,548 and rising to £38,833 per annum
Placed on: 22 November 2017 
Closing date:  1 January 2018.  Applications must be received by midnight of the closing date.
Expected interview date: approx. 10 Jan 2018
Expected start date: Feb 2018

Job description

We wish to appoint a Research Fellow in Chemical Biology/Medicinal Chemistry, which carries on from work published in ACS Chem. Biol., 2016, 11, 2265,  on rescuing wild-type p53 in Y220C mutant cancers. Around 100,000 cases of this tyrosine to cysteine mutation are found annually and these lead to thermal instability of the protein via the creation of a druggable cavity into which our molecules can fit and effectively stabilise the protein, preventing unfolding and rescuing apoptosis.

The project involves the synthesis of libraries of mainly small drug-like molecules for biological evaluation and x-ray structural studies by our collaborators (Prof. Sir Alan Fersht FRS, Cambridge, and Dr Andreas Joerger, DKTK, Frankfurt). 

Candidates with a PhD in medicinal chemistry or chemical biology are encouraged to apply. For further details on the Spencer group. The laboratories are equipped with state of the art parallel synthesis, microwave, automatic purification and evaporation, LC-MS and analytical equipment.

The University of Sussex values the diversity of its staff and students and we welcome applicants from all backgrounds

The School is committed to equality and valuing diversity, and currently holds an Athena SWAN Silver Award. Applications are particularly welcomed from women and black and minority ethnic candidates, who are under-represented in academic posts in Science, Technology, Engineering, Medicine and Mathematics (STEMM) at Sussex. The School of Life Sciences welcomes applications to academic posts from candidates who wish to work part-time or as job-sharers.

The University offers various schemes to provide real benefits to parents, these can be found at Family Friendly Policies

 Download job description and person specification Ref 2758 [PDF 126.29KB]

How to apply

Download our academic post application form [DOC 301.50KB] and personal details and equal opportunities form [DOC 162.50KB] and fill in all sections.

Email your completed application, and personal details and equal opportunities form, to 

You should attach your application form and all documents to the email (don't use a web-based upload/weblink service) and use the format job reference number / job title / your name in the subject line.

You can also send your application by post to Human Resources Division, Sussex House, University of Sussex, Falmer, Brighton, BN1 9RH.

Download our terms and conditions summary for Research Faculty Terms and Conditions [DOC 36.00KB]

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