School/department: School of Life Sciences - Genome Damage and Stability Centre
Hours: full time
Contract: fixed term for 3 years
Salary: starting at £32,004 and rising to £38,183 per annum
Closing date: 1 August 2017. Applications must be received by midnight of the closing date.
Expected interview date: Mid August 2017
Expected start date: 1 October 2017 (flexible)
Two post-doctoral research fellows are available for an initial period of 36 months within the laboratory of Dr Matt Neale in the Genome Damage and Stability Centre. These posts are funded as part of a five-year Wellcome Trust Investigator Award with flexible start dates possible through into 2018.
Our goal is to understand the mechanisms regulating the spatial distribution of genetic recombination during meiosis—a specialised cell division responsible for genome haploidisation during gametogenesis. We recently demonstrated that the distribution of meiotic DNA breaks (DSBs)—the precursors of genetic recombination—is non-random, being regulated by the evolutionarily-conserved DNA damage response (DDR) checkpoint protein Tel1 (ATM in mammals).
In this project we will build upon this exciting work, to test the manner in which chromosome structure shapes—and is shaped by—the process of genetic recombination.
About the positions
The project employs a S. cerevisiae model system, and will utilise a range of techniques including physical and genetic analyses of recombination and chromosome structure, molecular imaging, mathematical simulation, and bioinformatics. Candidates with demonstrable experience in these areas, and an interest and background in meiosis, chromosome biology and genetic recombination are strongly encouraged to apply.
For informal enquiries, please contact Matt Neale: firstname.lastname@example.org
Successful candidates will become part of a dynamic research team investigating complementary questions and will have the opportunity to extend their position within the duration of the Wellcome Trust Award (5 years).
Research lab and intellectual environment
As a research team, we are jointly funded by the BBSRC, the ERC, and the Wellcome Trust. Our broad interests are in the general mechanisms for detecting, processing, and repairing DNA breaks during the mitotic and meiotic cell cycle and in how these mechanisms influence genetic change.
The School of Life Sciences is at the forefront of research in the biological sciences in the UK, coming in the top 10 in the REF 2014.
The Genome Damage and Stability Centre is an internationally renowned research institute and is part of The School of Life Sciences (ranked in the top 10 in the REF 2014), and conducts research on cellular responses to DNA damage and their impact on genome instability and disease.
We provide a stimulating and supportive environment and our expertise covers a range of experimental systems.
Relevant papers from the Neale lab:
2016 Cooper, T.J., Garcia, V., and M. J. Neale.
Meiotic DSB patterning: A multifaceted process
Cell Cycle 15(1):13-21. doi: 10.1080/15384101.2015.1093709
2015 Garcia, V., Gray, S., Allison, R.M., Cooper, T.J., and M. J. Neale.
Tel1/ATM-mediated interference suppresses clustered meiotic DSB formation
Nature. Jan 5. doi: 10.1038/nature13993
2013 Gray, S, R. Allison, V. Garcia, A.S.H. Goldman and M. J. Neale.
Positive regulation of meiotic DNA double-strand break formation by activation of the DNA damage checkpoint kinase Mec1(ATR)
Open Biology 3(7):130019. doi:10.1098/rsob.130019
An overview of research within the Genome Stability theme can be found at School of Life Sciences
The School is committed to equality and valuing diversity, and currently holds an Athena SWAN Silver Award. Applications are particularly welcomed from women and black and minority ethnic candidates, who are under-represented in academic posts in science and engineering at Sussex.
The School of Life Sciences welcomes applications to academic posts from candidates who wish to work part-time or as job-sharers.
The University offers various schemes to provide real benefits to parents, these can be found at Family Friendly Policies
How to apply
Applications should be accompanied by a full CV, a statement of research interests and aspirations (not more than 4 pages), and the names of three academic referees.
Email your completed application and personal details and equal opportunities form to email@example.com
You should attach your application form and all documents to the email (don't use a web-based upload/weblink service) and use the format job reference number / job title / your name in the subject line.
You can also send your application by post to Human Resources Division, Sussex House, University of Sussex, Falmer, Brighton, BN1 9RH.